After upgrading simscan, mails did not seem to be scanned anymore.
In order to debug what was going on, I entered the following command in order to see what happened to QMail:
This injects a mail, stored in the file test directly into the QMail system. And simscan checks the environment variable SIMSCAN_DEBUG upon each invocation. The debug output was not self contained, I had to refer to the Simscan source code to see what actually went wrong.
It seems that per-domain checking was enabled. And since no domain was configured for this, it didn't check any of the incoming mails. I reinstalled the port simscan again, this time with the DOMAIN option disabled. After that, the scanner worked like a charm.
A bit strange, I thought portupgrade would leave the configuration alone when upgrading a port.